NovoCIB PNP Services

Therapeutic potential of PNP inhibitors PNP deficiency leads to T-lymphocytopenia, usually with no apparent effects on B-lymphocyte function. These symptoms suggest possible chemotherapeutic applications of potent inhibitors of PNP, as selective immunosuppressive agents, to treat T-cell leukemias or T-cell-mediated autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis . The decrease in plasma and urine levels of urate is an additional symptom of PNP deficiency. PNP inhibitors may contribute to treat hyperuricemic states, such as secondary or xanthine gout. Some PNP inhibitors have undergone clinical trials for the treatment of cutaneous T-cell lymphoma, acute lymphoblastic leukemia (ALL), HIV infections, and psoriasis.